The NovaKill™/scCO2 Process

Effective terminal sterilization using supercritical carbon dioxide.
White A, Burns D, Christensen TW.
Biotechnol 2006;123:504-15.

Inactivation of Bacterial Spores and Viruses in Biological Material Using Supercritical Carbon Dioxide with Sterilant.
Qiu Q-Q, Leamy P, Brittingham J, Pomerleau J, Kabaria N, Connor J.
J Biomed Mater Res Pt B: Appl Biomater 2009;91B:572-8.

Mechanism of Bacillus subtilis Spore Inactivation by and Resistance to Supercritical CO2 plus Peracetic
Setlow B, Korza G, Blatt KM, Fey JP and Setlow P.
Acid. J. Appl. Microbiol. 2016;120:57-69.

Sterilization of Bone Products

The Effect of Sterilization on the Mechanical Properties of Intact Rabbit Humeri in Three-Point Bending, Four-Point Bending and Torsion.
Russell NA, Rives A, Pelletier MH, Bruce WJ, Walsh WR.
Cell Tissue Bank 2013;14:231-242.

The Effect of Sterilization on the Dynamic Mechanical Properties of Paired Rabbit Cortical Bone.
Russell NA, Rives A, Bertollo N, Pelletier MH and Walsh WR.
J. Biomech. 2013;46:1670-5.

The Effect of Sterilization Methods on Osteoconductivity of Allograft Bone on a Critical-Sized Bilateral Tibia Defect Model in Rabbits.
Russell N, Oliver RA and Walsh WR.
Biomaterials 2013;34:8185-94.

The Effect of Supercritical Carbon Dioxide Sterilization on the Anisotropy of Bovine Cortical Bone.
Russell N, Rives A, Pelletier MH, Wang T and Walsh WR.
Cell Tissue Bank 2014;16:109-21.

Meniscal Allograft Sterilisation: Effect on Biomechanical and Histological Properties.
Bui D, Lovric V, Oliver R, Bertollo N, Broe D and Walsh WR.
Cell Tissue Bank 2015;16:467-75

Sterilization of Soft Tissue Products

Studies on the Sterilization of Human Bone and Tendon Musculoskeletal Allograft Tissue Using Supercritical Carbon Dioxide.
Nichols A, Burns DC, Christopher R.
J. Orthopaedics 2009; 6:e9.

Development of a Sterile Amniotic Membrane Tissue Graft Using Supercritical Carbon Dioxide.
Wehmeyer JL, Natesan S, Christy RJ.
Tissue Eng Part C Methods 2015;7:649-59.

Sterilization of Lung Matrices by Supercritical Carbon Dioxide.
Balestrini JL, Liu A, Gard AL, Huie J, Blatt KM, Schwan J, Zhao L, Broekelmann TJ, Mecham RP, Wilcox EC and Niklason LE.
Tissue Eng Part C Methods 2016;22:260-9.

Supercritical Carbon Dioxide-Based Sterilization of Decellularized Heart Valves.
Hennessy RS, Jana S, Tefft BJ, Helder MR, Young MD, Hennessy RR, Stoyles NJ, Lerman A.
JACC Basic Transl Sci. 2017;2:71-84.

Recellularization of a Novel Off-the-shelf Valve Following Xenogenic Implantation Into the Right Ventricular Outflow Tract.
Hennessy RS, Go JL, Hennessy RR, Tefft BJ, Jana S, Stoyles NJ, Al-Hijji MA, Thaden JJ, Pislaru SV, Simari RD, Stulak JM, Young MD, Lerman A.
PLoS One 2017;12:e0181614

Sterilization of Polymers and Hydrogels

Huie JL, Nichols JA, Fey JP, Burns DC, Potuck A and Chu CC.
Novel Supercritical Carbon Dioxide Sterilization of Absorbable Sutures and new Amino Acid-Based Biomaterials as Suture Coatings.
NovaScience Publications. Biodegradable Polymers. 2015;Vol.1: Advancement in Biodegradation Study and Applications Chapter 14 pp.381-406

Improved Sterilization of Sensitive Biomaterials with Supercritical Carbon Dioxide at Low Temperature.
Bernhardt A, Wehrl M, Paul B, Hochmuth T, Schumacher M, Schütz K, Gelinsky M.
PLoS One. 2015;10:e0129205.